{"id":59,"date":"2015-05-07T17:27:07","date_gmt":"2015-05-07T22:27:07","guid":{"rendered":"https:\/\/pjenkinslab.org\/?page_id=59"},"modified":"2024-03-14T11:45:03","modified_gmt":"2024-03-14T16:45:03","slug":"research","status":"publish","type":"page","link":"https:\/\/pjenkinslab.org\/index.php\/research\/","title":{"rendered":"Research"},"content":{"rendered":"<div id='revolutionslider_1'  class='avia-layerslider avia-revolutionslider main_color avia-shadow  avia-builder-el-0  el_before_av_section  avia-builder-el-first   container_wrap fullsize'  >\n\t\t\t<!-- START stadium REVOLUTION SLIDER 6.5.19 --><p class=\"rs-p-wp-fix\"><\/p>\n\t\t\t<rs-module-wrap id=\"rev_slider_2_1_wrapper\" data-source=\"gallery\" style=\"visibility:hidden;background:#E9E9E9;padding:0;margin:0px auto;margin-top:0;margin-bottom:0;\">\n\t\t\t\t<rs-module id=\"rev_slider_2_1\" style=\"\" data-version=\"6.5.19\">\n\t\t\t\t\t<rs-slides>\n\t\t\t\t\t\t<rs-slide style=\"position: absolute;\" data-key=\"rs-8\" data-title=\"Slide\" data-anim=\"ms:600;\" data-in=\"o:0;\" data-out=\"a:false;\">\n\t\t\t\t\t\t\t<img src=\"\/\/pjenkinslab.org\/wp-content\/plugins\/revslider\/public\/assets\/assets\/dummy.png\" alt=\"\" title=\"Research\" class=\"rev-slidebg tp-rs-img rs-lazyload\" data-lazyload=\"\/\/pjenkinslab.org\/wp-content\/uploads\/2015\/05\/MI-stadium-night-01.jpg\" data-no-retina>\n<!---->\t\t\t\t\t\t<\/rs-slide>\n\t\t\t\t\t\t<rs-slide style=\"position: absolute;\" data-key=\"rs-81\" data-title=\"Slide\" data-anim=\"ms:600;\" data-in=\"o:0;\" data-out=\"a:false;\">\n\t\t\t\t\t\t\t<img src=\"\/\/pjenkinslab.org\/wp-content\/plugins\/revslider\/public\/assets\/assets\/dummy.png\" alt=\"\" title=\"Research\" class=\"rev-slidebg tp-rs-img rs-lazyload\" data-lazyload=\"\/\/pjenkinslab.org\/wp-content\/uploads\/2015\/05\/MI-stadium-night-01.jpg\" data-no-retina>\n<!---->\t\t\t\t\t\t<\/rs-slide>\n\t\t\t\t\t<\/rs-slides>\n\t\t\t\t<\/rs-module>\n\t\t\t\t<script>\n\t\t\t\t\tsetREVStartSize({c: 'rev_slider_2_1',rl:[1240,1024,778,480],el:[],gw:[960],gh:[240],type:'standard',justify:'',layout:'fullwidth',mh:\"240\"});if (window.RS_MODULES!==undefined && window.RS_MODULES.modules!==undefined && window.RS_MODULES.modules[\"revslider21\"]!==undefined) {window.RS_MODULES.modules[\"revslider21\"].once = false;window.revapi2 = undefined;if (window.RS_MODULES.checkMinimal!==undefined) window.RS_MODULES.checkMinimal()}\n\t\t\t\t<\/script>\n\t\t\t<\/rs-module-wrap>\n\t\t\t<!-- END REVOLUTION SLIDER -->\n<\/div>\n<div id='av_section_1'  class='avia-section av-bmz5b-81e491f832e5709b7bd7db01eefa47d3 main_color avia-section-small avia-no-shadow  avia-builder-el-1  el_after_av_revolutionslider  el_before_av_section  avia-bg-style-scroll container_wrap fullsize'  ><div class='container av-section-cont-open' ><div class='template-page content  av-content-full alpha units'><div class='post-entry post-entry-type-page post-entry-59'><div class='entry-content-wrapper clearfix'>\n<div class='flex_column av-b2t2f-7b23b66453ac872b03fb00c3ddc904cb av_one_full  avia-builder-el-2  avia-builder-el-no-sibling  first flex_column_div '     ><section  class='av_textblock_section av-aby0j-8b7cbf734d2bbdebbeb3c26fdc6c9966'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h3 style=\"text-align: center;\">Our laboratory studies the basic cellular and molecular mechanisms underlying complex neuropsychiatric and neurodevelopmental diseases, such as bipolar disorder and autism spectrum disorders, as well as general mechanisms of plasma membrane organization in polarized cells.<\/h3>\n<\/div><\/section><\/div>\n\n<\/div><\/div><\/div><!-- close content main div --><\/div><\/div><div id='av_section_2'  class='avia-section av-zkdb-848bc979336b37bfe8c1a7f16383ae2b main_color avia-section-small avia-no-border-styling  avia-builder-el-4  el_after_av_section  el_before_av_section  avia-bg-style-scroll container_wrap fullsize'  ><div class='container av-section-cont-open' ><div class='template-page content  av-content-full alpha units'><div class='post-entry post-entry-type-page post-entry-59'><div class='entry-content-wrapper clearfix'>\n<div class='flex_column av-93e2v-25f7f6855b36acbf9225856aeac232d5 av_one_full  avia-builder-el-5  el_before_av_hr  avia-builder-el-first  first flex_column_div '     ><style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-8ubdr-48fcbf38bd597054c58f17949b1505a5\">\n#top .av_textblock_section.av-8ubdr-48fcbf38bd597054c58f17949b1505a5 .avia_textblock{\nfont-size:18px;\n}\n<\/style>\n<section  class='av_textblock_section av-8ubdr-48fcbf38bd597054c58f17949b1505a5'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h3><b>Our Focus<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Large scale genetic screens have identified many significant genes that contribute to neuropsychiatric and neurodevelopmental diseases, like bipolar disorder and autism spectrum disorders. What we lack is an understanding of how these genetic alterations impact protein function and ultimately brain activity and behavior.\u00a0 Ankyrins, encoded by the <\/span><em><span style=\"font-weight: 400;\">ANK1-3<\/span><\/em><span style=\"font-weight: 400;\"> genes, have been implicated in a wide range of brain diseases. Ankyrins are intracellular scaffolding proteins that have critical functions in the formation of plasma membrane domains in polarized cells throughout the body, especially in the brain. Our laboratory is interested in ankyrins, their protein partners, and how dysfunction of these protein complexes contributes to disease.<\/span><\/p>\n<\/div><\/section><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-6btz3-8c920832c918256e3f10d1a71cd0d8bd\">\n#top .hr.av-6btz3-8c920832c918256e3f10d1a71cd0d8bd{\nmargin-top:10px;\nmargin-bottom:10px;\n}\n.hr.av-6btz3-8c920832c918256e3f10d1a71cd0d8bd .hr-inner{\nwidth:100%;\nborder-color:#999999;\n}\n<\/style>\n<div  class='hr av-6btz3-8c920832c918256e3f10d1a71cd0d8bd hr-custom  avia-builder-el-7  el_after_av_one_full  avia-builder-el-last  hr-center hr-icon-no'><span class='hr-inner inner-border-av-border-thin'><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n\n<\/div><\/div><\/div><!-- close content main div --><\/div><\/div><div id='av_section_3'  class='avia-section av-5gcbz-989a3e2802c32f008ca35032b99b156f main_color avia-section-small avia-no-border-styling  avia-builder-el-8  el_after_av_section  el_before_av_section  avia-bg-style-scroll container_wrap fullsize'  ><div class='container av-section-cont-open' ><div class='template-page content  av-content-full alpha units'><div class='post-entry post-entry-type-page post-entry-59'><div class='entry-content-wrapper clearfix'>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-3slsj-74c5273e54dbbfe55b8cce6e06784d63\">\n.flex_column.av-3slsj-74c5273e54dbbfe55b8cce6e06784d63{\n-webkit-border-radius:0px 0px 0px 0px;\n-moz-border-radius:0px 0px 0px 0px;\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div class='flex_column av-3slsj-74c5273e54dbbfe55b8cce6e06784d63 av_two_third  avia-builder-el-9  el_before_av_one_third  avia-builder-el-first  first flex_column_div av-zero-column-padding '     ><style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-36587-e660594d07be0f66cdfef4846a0677fb\">\n#top .av_textblock_section.av-36587-e660594d07be0f66cdfef4846a0677fb .avia_textblock{\nfont-size:18px;\n}\n<\/style>\n<section  class='av_textblock_section av-36587-e660594d07be0f66cdfef4846a0677fb'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h3><b>Ankyrin-G in Bipolar Disorder<\/b><\/h3>\n<p>Multiple genetic studies have shown that the <em>ANK3 <\/em>gene is highly associated with bipolar disorder (BD). The <em>ANK3 <\/em>gene encodes ankyrin-G, a scaffolding protein involved in the formation of the axon initial segment (AIS), nodes of Ranvier, and GABAergic synapses. We generated a <em>Ank3<\/em> mutant mouse that has striking reductions in inhibitory neurotransmission. Importantly, alterations in inhibitory signaling causes an excitatory \/ inhibitory imbalance that has also been observed in BD patients. We recently identified a BD family carrying the same <em>ANK3 <\/em>variant, highlighting the potential impact of ankyrin-dependent inhibitory signaling. Our team is investigating how common BD therapeutics affect ankyrin-dependent inhibitory signaling in <em>Ank3<\/em> mutant mouse models.<\/p>\n<\/div><\/section><\/div><div class='flex_column av-hupr-66902e0567b9374f01c29445227fefc5 av_one_third  avia-builder-el-11  el_after_av_two_third  el_before_av_hr  flex_column_div '     ><style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-4edif-4b0517fb330d144a333bb8b910ba8935\">\n.avia-image-container.av-4edif-4b0517fb330d144a333bb8b910ba8935 img.avia_image{\nbox-shadow:none;\n}\n.avia-image-container.av-4edif-4b0517fb330d144a333bb8b910ba8935 .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-4edif-4b0517fb330d144a333bb8b910ba8935 av-styling- avia-align-center  avia-builder-el-12  avia-builder-el-no-sibling '   itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><img decoding=\"async\" class='wp-image-1040 avia-img-lazy-loading-not-1040 avia_image ' src=\"https:\/\/pjenkinslab.org\/wp-content\/uploads\/2015\/05\/Ank3-845x684.jpg\" alt='' title='Ank3'  height=\"684\" width=\"845\"  itemprop=\"thumbnailUrl\" srcset=\"https:\/\/pjenkinslab.org\/wp-content\/uploads\/2015\/05\/Ank3-845x684.jpg 845w, https:\/\/pjenkinslab.org\/wp-content\/uploads\/2015\/05\/Ank3-495x400.jpg 495w\" sizes=\"(max-width: 845px) 100vw, 845px\" \/><\/div><\/div><\/div><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-2unez-c2155a6bd175e23745bc2ff8e44ebdc3\">\n#top .hr.av-2unez-c2155a6bd175e23745bc2ff8e44ebdc3{\nmargin-top:10px;\nmargin-bottom:10px;\n}\n.hr.av-2unez-c2155a6bd175e23745bc2ff8e44ebdc3 .hr-inner{\nwidth:100%;\nborder-color:#999999;\n}\n<\/style>\n<div  class='hr av-2unez-c2155a6bd175e23745bc2ff8e44ebdc3 hr-custom  avia-builder-el-13  el_after_av_one_third  avia-builder-el-last  hr-center hr-icon-no'><span class='hr-inner inner-border-av-border-thin'><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n\n<\/div><\/div><\/div><!-- close content main div --><\/div><\/div><div id='av_section_4'  class='avia-section av-5gcbz-14-add553fb651beec2474149fc8db78152 main_color avia-section-small avia-no-border-styling  avia-builder-el-14  el_after_av_section  el_before_av_section  avia-bg-style-scroll container_wrap fullsize'  ><div class='container av-section-cont-open' ><div class='template-page content  av-content-full alpha units'><div class='post-entry post-entry-type-page post-entry-59'><div class='entry-content-wrapper clearfix'>\n<div class='flex_column av-hupr-11-6bedcac0e4c64c7c0e8cdb6906475b4d av_one_third  avia-builder-el-15  el_before_av_two_third  avia-builder-el-first  first flex_column_div '     ><style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-4edif-10-945c3a190964f1be167690e7d57724fa\">\n.avia-image-container.av-4edif-10-945c3a190964f1be167690e7d57724fa img.avia_image{\nbox-shadow:none;\n}\n.avia-image-container.av-4edif-10-945c3a190964f1be167690e7d57724fa .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-4edif-10-945c3a190964f1be167690e7d57724fa av-styling- avia-align-center  avia-builder-el-16  avia-builder-el-no-sibling '   itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><img decoding=\"async\" class='wp-image-1042 avia-img-lazy-loading-not-1042 avia_image ' src=\"https:\/\/pjenkinslab.org\/wp-content\/uploads\/2015\/05\/AnkG-and-B.jpg\" alt='' title='AnkG and B'  height=\"550\" width=\"548\"  itemprop=\"thumbnailUrl\" srcset=\"https:\/\/pjenkinslab.org\/wp-content\/uploads\/2015\/05\/AnkG-and-B.jpg 548w, https:\/\/pjenkinslab.org\/wp-content\/uploads\/2015\/05\/AnkG-and-B-80x80.jpg 80w, https:\/\/pjenkinslab.org\/wp-content\/uploads\/2015\/05\/AnkG-and-B-300x300.jpg 300w, https:\/\/pjenkinslab.org\/wp-content\/uploads\/2015\/05\/AnkG-and-B-36x36.jpg 36w, https:\/\/pjenkinslab.org\/wp-content\/uploads\/2015\/05\/AnkG-and-B-180x180.jpg 180w, https:\/\/pjenkinslab.org\/wp-content\/uploads\/2015\/05\/AnkG-and-B-120x120.jpg 120w, https:\/\/pjenkinslab.org\/wp-content\/uploads\/2015\/05\/AnkG-and-B-450x452.jpg 450w\" sizes=\"(max-width: 548px) 100vw, 548px\" \/><\/div><\/div><\/div><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-3slsj-13-fae936a2eada19df52868880c0d293ce\">\n.flex_column.av-3slsj-13-fae936a2eada19df52868880c0d293ce{\n-webkit-border-radius:0px 0px 0px 0px;\n-moz-border-radius:0px 0px 0px 0px;\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div class='flex_column av-3slsj-13-fae936a2eada19df52868880c0d293ce av_two_third  avia-builder-el-17  el_after_av_one_third  el_before_av_hr  flex_column_div av-zero-column-padding '     ><style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-36587-12-090e92e70b68ea3341e933da4113d050\">\n#top .av_textblock_section.av-36587-12-090e92e70b68ea3341e933da4113d050 .avia_textblock{\nfont-size:18px;\n}\n<\/style>\n<section  class='av_textblock_section av-36587-12-090e92e70b68ea3341e933da4113d050'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h3><b>Ankyrin-B in Autism Spectrum Disorders<\/b><\/h3>\n<p>Multiple genetic studies have shown that the <em>ANK2<\/em> gene is highly associated with autism spectrum disorder (ASD). <em>ANK2<\/em> encodes ankyrin-B, which has been found to localize in the dendrites, however its role there remains poorly understood. Recent data show that Nav1.2, encoded by <em>SCN2A<\/em>, is critical for normal dendritic function. <em>SCN2A<\/em> is the top gene associated with ASD. We hypothesize that Nav1.2 is recruited to, and maintained at, the dendrites by ankyrin-B. We aim to understand how these two genes, <em>ANK2<\/em> and <em>SCN2A<\/em>, are linked at the molecular level and how dysfunction of this pathway contributes to disease.<\/p>\n<\/div><\/section><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-2unez-9-502d192b3937e70f49fa4fc3724993d3\">\n#top .hr.av-2unez-9-502d192b3937e70f49fa4fc3724993d3{\nmargin-top:10px;\nmargin-bottom:10px;\n}\n.hr.av-2unez-9-502d192b3937e70f49fa4fc3724993d3 .hr-inner{\nwidth:100%;\nborder-color:#999999;\n}\n<\/style>\n<div  class='hr av-2unez-9-502d192b3937e70f49fa4fc3724993d3 hr-custom  avia-builder-el-19  el_after_av_two_third  avia-builder-el-last  hr-center hr-icon-no'><span class='hr-inner inner-border-av-border-thin'><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n\n<\/div><\/div><\/div><!-- close content main div --><\/div><\/div><div id='av_section_5'  class='avia-section av-5gcbz-8-be2284dabccae0922a893a788690cbdd main_color avia-section-small avia-no-border-styling  avia-builder-el-20  el_after_av_section  el_before_av_one_full  avia-bg-style-scroll container_wrap fullsize'  ><div class='container av-section-cont-open' ><div class='template-page content  av-content-full alpha units'><div class='post-entry post-entry-type-page post-entry-59'><div class='entry-content-wrapper clearfix'>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-3slsj-6-b8511873d31b574b62c6fdde05f01b34\">\n.flex_column.av-3slsj-6-b8511873d31b574b62c6fdde05f01b34{\n-webkit-border-radius:0px 0px 0px 0px;\n-moz-border-radius:0px 0px 0px 0px;\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div class='flex_column av-3slsj-6-b8511873d31b574b62c6fdde05f01b34 av_two_third  avia-builder-el-21  el_before_av_one_third  avia-builder-el-first  first flex_column_div av-zero-column-padding '     ><style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-36587-5-77cfa090c78f3fe76eab8c1d7ecac900\">\n#top .av_textblock_section.av-36587-5-77cfa090c78f3fe76eab8c1d7ecac900 .avia_textblock{\nfont-size:18px;\n}\n<\/style>\n<section  class='av_textblock_section av-36587-5-77cfa090c78f3fe76eab8c1d7ecac900'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h3><b>Mechanisms Underlying Ankyrin Targeting in Polarized Cells<\/b><\/h3>\n<p>Ankyrins are important for localizing their binding partners at specific membrane domains, but very little is known about how ankyrins themselves reach these membrane sites. Previous work has demonstrated that ankyrin-G relies on the post-translational modification, S-palmitoylation, which is the addition of a 16-carbon fatty acid to cysteine residues of proteins, to localize specifically at the lateral membrane of epithelial cells and at the AIS of neurons. Our laboratory is investigating whether ankyrin-B also undergoes S-palmitoylation to regulate its localization and downstream functions. These studies help us understand how alterations in these localization mechanisms may contribute to ankyrin-associated disease such as BD or ASD.<\/p>\n<\/div><\/section><\/div><div class='flex_column av-hupr-7-3187d9abeb58ae041886b70002bb0d13 av_one_third  avia-builder-el-23  el_after_av_two_third  el_before_av_hr  flex_column_div '     ><style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-k8kjespc-34f7b8f1640c415a1919387c7e670696\">\n.avia-image-container.av-k8kjespc-34f7b8f1640c415a1919387c7e670696 img.avia_image{\nbox-shadow:none;\n}\n.avia-image-container.av-k8kjespc-34f7b8f1640c415a1919387c7e670696 .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-k8kjespc-34f7b8f1640c415a1919387c7e670696 av-styling- avia-align-left  avia-builder-el-24  avia-builder-el-no-sibling '   itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><img decoding=\"async\" class='wp-image-1052 avia-img-lazy-loading-not-1052 avia_image ' src=\"https:\/\/pjenkinslab.org\/wp-content\/uploads\/2015\/05\/palm2.jpg\" alt='' title='palm2'  height=\"1187\" width=\"996\"  itemprop=\"thumbnailUrl\" srcset=\"https:\/\/pjenkinslab.org\/wp-content\/uploads\/2015\/05\/palm2.jpg 996w, https:\/\/pjenkinslab.org\/wp-content\/uploads\/2015\/05\/palm2-252x300.jpg 252w, https:\/\/pjenkinslab.org\/wp-content\/uploads\/2015\/05\/palm2-768x915.jpg 768w, https:\/\/pjenkinslab.org\/wp-content\/uploads\/2015\/05\/palm2-864x1030.jpg 864w, https:\/\/pjenkinslab.org\/wp-content\/uploads\/2015\/05\/palm2-592x705.jpg 592w, https:\/\/pjenkinslab.org\/wp-content\/uploads\/2015\/05\/palm2-450x536.jpg 450w\" sizes=\"(max-width: 996px) 100vw, 996px\" \/><\/div><\/div><\/div><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-2unez-4-0406722b229c910c889f3f2c83f68f73\">\n#top .hr.av-2unez-4-0406722b229c910c889f3f2c83f68f73{\nmargin-top:10px;\nmargin-bottom:10px;\n}\n.hr.av-2unez-4-0406722b229c910c889f3f2c83f68f73 .hr-inner{\nwidth:100%;\nborder-color:#999999;\n}\n<\/style>\n<div  class='hr av-2unez-4-0406722b229c910c889f3f2c83f68f73 hr-custom  avia-builder-el-25  el_after_av_one_third  avia-builder-el-last  hr-center hr-icon-no'><span class='hr-inner inner-border-av-border-thin'><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n<\/div><\/div><\/div><!-- close content main div --><\/div><\/div><div id='after_section_5'  class='main_color av_default_container_wrap container_wrap fullsize'  ><div class='container av-section-cont-open' ><div class='template-page content  av-content-full alpha units'><div class='post-entry post-entry-type-page post-entry-59'><div class='entry-content-wrapper clearfix'>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" 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