{"id":1241,"date":"2023-03-09T10:18:24","date_gmt":"2023-03-09T15:18:24","guid":{"rendered":"https:\/\/pjenkinslab.org\/?p=1241"},"modified":"2023-03-09T10:18:46","modified_gmt":"2023-03-09T15:18:46","slug":"renes-paper-on-the-role-of-syt-7-in-the-splanchnic-nerve-chromaffin-cell-synapse-is-accepted","status":"publish","type":"post","link":"https:\/\/pjenkinslab.org\/index.php\/2023\/03\/09\/renes-paper-on-the-role-of-syt-7-in-the-splanchnic-nerve-chromaffin-cell-synapse-is-accepted\/","title":{"rendered":"Ren\u00e9&#8217;s paper on the role of Syt-7 in the splanchnic nerve-chromaffin cell synapse is accepted."},"content":{"rendered":"<div class='flex_column av-av_one_third-7714eba142aeda1f8b5272a3c372b279 av_one_third  avia-builder-el-0  el_before_av_two_third  avia-builder-el-first  first flex_column_div '     ><style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-lf1927s3-eb93fc19345783fefb298b9886e24253\">\n.avia-image-container.av-lf1927s3-eb93fc19345783fefb298b9886e24253 img.avia_image{\nbox-shadow:none;\n}\n.avia-image-container.av-lf1927s3-eb93fc19345783fefb298b9886e24253 .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-lf1927s3-eb93fc19345783fefb298b9886e24253 av-styling- avia-align-center  avia-builder-el-1  avia-builder-el-no-sibling '   itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><img decoding=\"async\" class='wp-image-1242 avia-img-lazy-loading-not-1242 avia_image ' src=\"https:\/\/pjenkinslab.org\/wp-content\/uploads\/2023\/03\/NSL.jpg\" alt='' title='NSL'  height=\"768\" width=\"576\"  itemprop=\"thumbnailUrl\" srcset=\"https:\/\/pjenkinslab.org\/wp-content\/uploads\/2023\/03\/NSL.jpg 576w, https:\/\/pjenkinslab.org\/wp-content\/uploads\/2023\/03\/NSL-225x300.jpg 225w, https:\/\/pjenkinslab.org\/wp-content\/uploads\/2023\/03\/NSL-529x705.jpg 529w\" sizes=\"(max-width: 576px) 100vw, 576px\" \/><\/div><\/div><\/div><\/div><div class='flex_column av-av_two_third-f1c518e9ff58e869f80c8f093487abc9 av_two_third  avia-builder-el-2  el_after_av_one_third  avia-builder-el-last  flex_column_div '     ><section  class='av_textblock_section av-lf19776a-a06ebe346661bc47fa1a6fedd3e0813b'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><p>Ren\u00e9&#8217;s paper &#8220;Synaptotagmin-7 facilitates acetylcholine release in splanchnic nerve-chromaffin cell synapses during nerve activity&#8221; , in collaboration with Dr. Arun Anantharam at the University of Toledo, was accepted for publication in Neuroscience Letters. The sympathetic nervous system and the adrenal medulla are activated in response to disturbances that threaten homeostasis. Preganglionic splanchnic fibers convey descending sympathetic information to the adrenal medulla, where they synapse onto chromaffin cells that secrete catecholamines and vasoactive peptides. This study shows that synaptotagmin-7 (Syt7), a ubiquitous Ca 2+ -binding protein, is expressed within the fibers that innervate the adrenal medulla and that its absence can alter synaptic transmission in the preganglionic terminals of chromaffin cells. The lack of Syt7 results in a decrease in synaptic strength and neuronal short-term plasticity. These findings reveal a role for Syt7 at the splanchnic-chromaffin cell synapse and suggest that it has actions at synaptic terminals that are conserved across central and peripheral branches of the nervous system. Congrats to Ren\u00e9 and the rest of the team! Read more <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36796621\/\">here.\u00a0<\/a><\/p>\n<\/div><\/section><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":1242,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/pjenkinslab.org\/index.php\/wp-json\/wp\/v2\/posts\/1241"}],"collection":[{"href":"https:\/\/pjenkinslab.org\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pjenkinslab.org\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pjenkinslab.org\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/pjenkinslab.org\/index.php\/wp-json\/wp\/v2\/comments?post=1241"}],"version-history":[{"count":2,"href":"https:\/\/pjenkinslab.org\/index.php\/wp-json\/wp\/v2\/posts\/1241\/revisions"}],"predecessor-version":[{"id":1244,"href":"https:\/\/pjenkinslab.org\/index.php\/wp-json\/wp\/v2\/posts\/1241\/revisions\/1244"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pjenkinslab.org\/index.php\/wp-json\/wp\/v2\/media\/1242"}],"wp:attachment":[{"href":"https:\/\/pjenkinslab.org\/index.php\/wp-json\/wp\/v2\/media?parent=1241"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pjenkinslab.org\/index.php\/wp-json\/wp\/v2\/categories?post=1241"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pjenkinslab.org\/index.php\/wp-json\/wp\/v2\/tags?post=1241"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}