{"id":1246,"date":"2023-04-20T14:45:52","date_gmt":"2023-04-20T19:45:52","guid":{"rendered":"https:\/\/pjenkinslab.org\/?p=1246"},"modified":"2023-04-21T14:46:27","modified_gmt":"2023-04-21T19:46:27","slug":"renes-co-first-author-publication-is-accepted-in-plos-biology","status":"publish","type":"post","link":"https:\/\/pjenkinslab.org\/index.php\/2023\/04\/20\/renes-co-first-author-publication-is-accepted-in-plos-biology\/","title":{"rendered":"Ren\u00e9&#8217;s co-first author publication is accepted in PLOS Biology!"},"content":{"rendered":"<div class='flex_column av-5oiuou-c0490c7ed1307df1899b05e4463ca075 av_one_third  avia-builder-el-0  el_before_av_two_third  avia-builder-el-first  first flex_column_div '     ><style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-4hpsam-2759bfee5850ef70992a1c8c718fbcf6\">\n.avia-image-container.av-4hpsam-2759bfee5850ef70992a1c8c718fbcf6 img.avia_image{\nbox-shadow:none;\n}\n.avia-image-container.av-4hpsam-2759bfee5850ef70992a1c8c718fbcf6 .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-4hpsam-2759bfee5850ef70992a1c8c718fbcf6 av-styling- avia-align-center  avia-builder-el-1  avia-builder-el-no-sibling '   itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><img decoding=\"async\" class='wp-image-1268 avia-img-lazy-loading-not-1268 avia_image ' src=\"https:\/\/pjenkinslab.org\/wp-content\/uploads\/2023\/04\/Chandeliers-in-the-brain-232x300.jpg\" alt='' title='Chandeliers in the brain'  height=\"300\" width=\"232\"  itemprop=\"thumbnailUrl\" srcset=\"https:\/\/pjenkinslab.org\/wp-content\/uploads\/2023\/04\/Chandeliers-in-the-brain-232x300.jpg 232w, https:\/\/pjenkinslab.org\/wp-content\/uploads\/2023\/04\/Chandeliers-in-the-brain-768x993.jpg 768w, https:\/\/pjenkinslab.org\/wp-content\/uploads\/2023\/04\/Chandeliers-in-the-brain-545x705.jpg 545w, https:\/\/pjenkinslab.org\/wp-content\/uploads\/2023\/04\/Chandeliers-in-the-brain.jpg 791w\" sizes=\"(max-width: 232px) 100vw, 232px\" \/><\/div><\/div><\/div><\/div><div class='flex_column av-2gewam-320609ab33394a3b052008dde5e8cbc7 av_two_third  avia-builder-el-2  el_after_av_one_third  avia-builder-el-last  flex_column_div '     ><section  class='av_textblock_section av-lf19e92e-a5f85d83f7f7d5a425188cc28db15dcc'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><p>Ren\u00e9&#8217;s co-first author publication, titled &#8220;DSCAM gene triplication causes excessive GABAergic synapses in the neocortex in Down syndrome mouse models&#8221; was accepted for publication in <em>PLOS Biology<\/em>. This was a collaborative effort between our group and the Bing Ye lab in the Life Science Institute at the University of Michigan. Down syndrome is caused by the trisomy of human chromosome 21 (HSA21). The Down syndrome cell adhesion molecule (DSCAM) gene is located on HSA21. In this study, we investigated the role of DSCAM in regulating GABAergic synapses formed on neocortical pyramidal neurons in the Ts65Dn mouse model for Down syndrome, where DSCAM is overexpressed. We found that excessive GABAergic innervations of cortical Pyramidal neurons (PyNs) by basket and chandelier cells are increased in this model. However, genetic normalization of DSCAM expression rescues this excessive innervation and inhibition of PyNs. Conversely, loss of DSCAM impairs GABAergic synapse development and function. These findings demonstrate that DSCAM overexpression causes excessive GABAergic innervation and synaptic transmission in the neocortex of Down syndrome mouse models. They also suggest that dysregulated DSCAM levels could be a pathogenic driver in related neurological disorders. Congrats, Ren\u00e9 and team! Read more<a href=\"https:\/\/journals.plos.org\/plosbiology\/article?id=10.1371\/journal.pbio.3002078\"> here.<\/a><\/p>\n<\/div><\/section><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":1268,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/pjenkinslab.org\/index.php\/wp-json\/wp\/v2\/posts\/1246"}],"collection":[{"href":"https:\/\/pjenkinslab.org\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pjenkinslab.org\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pjenkinslab.org\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/pjenkinslab.org\/index.php\/wp-json\/wp\/v2\/comments?post=1246"}],"version-history":[{"count":3,"href":"https:\/\/pjenkinslab.org\/index.php\/wp-json\/wp\/v2\/posts\/1246\/revisions"}],"predecessor-version":[{"id":1270,"href":"https:\/\/pjenkinslab.org\/index.php\/wp-json\/wp\/v2\/posts\/1246\/revisions\/1270"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pjenkinslab.org\/index.php\/wp-json\/wp\/v2\/media\/1268"}],"wp:attachment":[{"href":"https:\/\/pjenkinslab.org\/index.php\/wp-json\/wp\/v2\/media?parent=1246"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pjenkinslab.org\/index.php\/wp-json\/wp\/v2\/categories?post=1246"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pjenkinslab.org\/index.php\/wp-json\/wp\/v2\/tags?post=1246"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}