The 2015 FASEB Summer Research Conference on Protein Lipidation, Signaling and Membrane Domains was held July 19-24 in Saxton’s River, Vermont. Thanks to Mike Shipston, Masaki Fukata, Carol Williams, and Chris Hrycyna for organizing such a great meeting. Vermont is absolutely stunning. Some really great science was presented, much fun was had at the fireside chats, and we even formed the very first FASEB Lipidation meeting “lipid raft”. Paul shared recent work on palmitoylation-dependent ankyrin-G/spectrin domains and their role in epithelial lateral membrane formation.