Large scale genetic screens have identified many significant genes that contribute to neuropsychiatric and neurodevelopmental diseases, like bipolar disorder and autism spectrum disorders. What we lack is an understanding of how these genetic alterations impact protein function and ultimately brain activity and behavior. Ankyrins, encoded by the ANK1-3 genes, have been implicated in a wide range of brain diseases. Ankyrins are intracellular scaffolding proteins that have critical functions in the formation of plasma membrane domains in polarized cells throughout the body, especially in the brain. Our laboratory is interested in ankyrins, their protein partners, and how dysfunction of these protein complexes contributes to disease.